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Sunday, November 20, 2011

Henk and Fisher's team investigated the genetics of all the samples by studying certain .....



The discovery of penicillin kick-started the antibiotic revolution. But a forensic-style investigation of the lab in which Alexander Fleming discovered the world-famous.........






The discovery of penicillin kick-started the antibiotic revolution. But a forensic-style investigation of the lab in which Alexander Fleming discovered the world-famous fungus suggests the Nobel prizewinner's find has been misunderstood for 80 years.
Fleming returned from a family vacation in August 1928 to find that a fungus had contaminated the samples of bacteria he had left in his lab, and that it was evidently a bacteria killer. Figuring that the fungus was secreting something that could be useful in treating human bacterial infections, Fleming sent his samples off to researchers in the US. They identified the fungus as Penicillium chrysogenum and looked for similar strains to find the one that would yield the largest antibiotic secretions. The hero strain came from a mouldy cantaloupe melon, and was tweaked to produce the penicillin used today.
Daniel Henk, Matthew Fisher and their colleagues at Imperial College London took a closer look at the fungal samples still preserved in Fleming's lab in London, now a museum. They even swabbed his old notebook. They then compared them with fungal samples collected by 300 volunteers around the world.
Henk and Fisher's team investigated the genetics of all the samples by studying certain easily recognised chunks of the genome: these don't tend to code for specific proteins, but are characterised by particular repeating patterns of short DNA sequences.

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